… M–P, Ppy behaves slightly different from the other hormones and cannot be detected until
e11.5, when it suddenly appears in both the dorsal and ventral pancreas rudiments. O and P, …

Cell replacement therapy could represent an attractive alternative to insulin injections for
the treatment of diabetes. However, this approach requires a thorough understanding of the …

Abstract Development of endocrine cells in the endoderm involves Atonal and Achaete/Scute-related
basic helix-loop-helix (bHLH) proteins. These proteins also serve as neuronal …

Embryoid bodies ( EBs ) have been popular in vitro differentiation models for pluripotent
stem cells for more than five decades. Initially, defined as aggregates formed by embryonal …

During vertebrate development, the specification of distinct cell types is thought to be
controlled by inductive signals acting at different concentration thresholds 1 . The degree of …

Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic α cells in
response to low blood glucose. To examine the role of glucagon in glucose homeostasis, …

… gene family with a potential role in islet of Langerhans genesis, we undertook a search
combining in silico and nested-PCR, using a mouse cDNA pancreas library as a template (P. …

We have previously reported that the loss of Arx and/or Pax4 gene activity leads to a shift in
the fate of the different endocrine cell subtypes in the mouse pancreas, without affecting the …

… population represents exocrine precursor cells that express p 4 8 - PTF 1 . By conducting
an extensive marker analysis, combined with an evaluation of the proliferative status of cell …

Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets
of Langerhans, followed by the selective and progressive destruction of insulin-secreting …