User profiles for P. Sham
 | Pak ShamDepartment of Psychiatry, The University of Hong Kong Verified email at hku.hk Cited by 144539 |
DNA pooling: a tool for large-scale association studies
… & Sham, PC Efficient SNP-based tests of association for quantitative phenotypes using
pooled DNA. GeneScreen 1, 143–150 (2001).A mathematical description of the optimal pooling …
pooled DNA. GeneScreen 1, 143–150 (2001).A mathematical description of the optimal pooling …
Statistical power and significance testing in large-scale genetic studies
PC Sham, SM Purcell - Nature Reviews Genetics, 2014 - nature.com
… P(P ≤ α | H 1 ) as the average statistical power of all SNPs for which H 1 is true. This formula
indicates that, when a study is inadequately powered, there is an increase in the proportion …
indicates that, when a study is inadequately powered, there is an increase in the proportion …
A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder
Schizophrenia and mania have a number of symptoms and epidemiological characteristics
in common, and both respond to dopamine blockade. Family, twin and molecular genetic …
in common, and both respond to dopamine blockade. Family, twin and molecular genetic …
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
[PDF][PDF] PLINK: a tool set for whole-genome association and population-based linkage analyses
… In fact, if we divide the sample J56 P p 9 # 10 into individuals … ), N p 213 N p 333 then all
instances of genotyping failure at … It J13 P p 7.6 # 10 would seem that, in this particular case, …
instances of genotyping failure at … It J13 P p 7.6 # 10 would seem that, in this particular case, …
[PDF][PDF] Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
… variance components methods of linkage and association mapping (Sham et al., 2000). The
use of such equations greatly speeds up power calculation and allows a more comprehensive …
use of such equations greatly speeds up power calculation and allows a more comprehensive …
The heritability of bipolar affective disorder and the genetic relationship to unipolar depression
Background Twin studies of bipolar affective disorder (BPD) have either been small or have
not used explicit diagnostic criteria. There has been little use of genetic model fitting and no …
not used explicit diagnostic criteria. There has been little use of genetic model fitting and no …
Stress and psychological distress among SARS survivors 1 year after the outbreak
…, V Cheung, C Cheung, PC Sham… - The Canadian …, 2007 - journals.sagepub.com
Objective: Our study examined the stress level and psychological distress of severe acute
respiratory syndrome (SARS) survivors 1 year after the outbreak. Method: During the SARS …
respiratory syndrome (SARS) survivors 1 year after the outbreak. Method: During the SARS …
A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.
…, GW Roberts, E Smeraldi, G Kirov, P Sham… - Molecular …, 1996 - europepmc.org
The serotonin transporter (5-HTT) is a candidate locus for aetiological involvement in
affective disorders. Biochemical studies in suicides and depressed patients suggest that 5-HT …
affective disorders. Biochemical studies in suicides and depressed patients suggest that 5-HT …
The support of human genetic evidence for approved drug indications
… For the variants, traits and P values reported, we removed any duplicate entries found
across the various GWASdb data sources. For the purposes of this study, we set a …
across the various GWASdb data sources. For the purposes of this study, we set a …