Accumulating evidence indicates that some protein-coding genes have originated de novo
from previously non-coding genomic sequences. However, the processes underlying de …

Cells express thousands of transcripts that show weak coding potential. Known as long non-coding
RNAs (lncRNAs), they typically contain short open reading frames (ORFs) having no …

… In the case of lncRNAs, translation was positively associated with ORF length (Wilcoxon
test, p-value < 10-5), but we did not detect any relationship between translation status and …

… The composite ratio for dORFs produced a ratio of 1.29, still significantly above the expected
value for neutral mutation but at a much lower level than the uORFs (p < 0.01). This value …

The birth of genes that encode new protein sequences is a major source of evolutionary
innovation. However, we still understand relatively little about how these genes come into being …

The increasing volume of ribosome profiling (Ribo-seq) data, computational complexity of
its data processing and operational handicap of related analytical procedures present a …

Small proteins of <51 amino acids are abundant across all domains of life, but they are often
overlooked because their small size makes them difficult to predict computationally and they …

… This lack of phylogenetic signal is unexpected, since the taxonomic sampling is much deeper
around our focal species P. pacificus (Figure 1A) and encompasses the two sister species, …