An overview of the metallurgical reactions during the vacuum sintering process of powder
mixtures for the manufacture of cermets is presented. The relatively complex phase reactions …

Prodrugs are an established concept to overcome barriers to a drug’s usefulness. In Germany,
about 6.9% of all marketed medicines can be classified as prodrugs, an estimate based …

Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an
approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (…

To date, there are no effective targeted pan-KRAS therapies. In-depth characterization of BI-3406
activity and identification of MEK inhibitors as effective combination partners provide …

Technically relevant solid state properties of the hot-pressed group IVb carbonitrides Ti(C x
N 1−x ) ≈1.00 , Ti(C x N 1−x ) 0.82 , Zr(C x N 1−x ) ≈1.00 and Hf(C x N 1−x ) ≈1.00 , such …

Hardmetals or cemented carbides (sometimes less accurately called sin tered carbides) are
composite materials with one or more hard but rela tively brittle components and a ductile …

Presently available data on the elastic properties of transition metal carbides, nitrides and
carbonitrides are critically reviewed. It is shown that a lot of information is available on binary …

The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies,
including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with …

In high and low pressure experiments in the Mo-N system the solidus line (α + L) and the
composition and temperature of the eutectic (L = α-Mo + γ-Mo 2 N) have been determined. Mo …

Synopsis The impressive history of hardmetals starts with the Schröter Patent and is then
followed by the first hardmetal company, Krupp-WIDIA. Metallwerk Plansee has also played an …