A population can adapt to a rapid environmental change or habitat expansion in two ways. It
may adapt either through new beneficial mutations that subsequently sweep through the …

In the classical model of molecular adaptation, a favored allele derives from a single mutational
origin. This ignores that beneficial alleles can enter a population recurrently, either by …

… In this study, Pennings and Hermisson use analytical tools and coalescent simulations to
describe this soft-sweep pattern. They show that this pattern is characterized by strong linkage …

The tempo and mode of adaptive evolution determine how natural selection shapes patterns
of genetic diversity in DNA polymorphism data. While slow mutation‐limited adaptation …

… In Pennings, 13 it was shown that the high probability of resistance after sdNVP is likely due
to the combination of monotherapy with a high abundance of pre-existing NNRTI mutations. …

Infections with rapidly evolving pathogens are often treated using combinations of drugs with
different mechanisms of action. One of the major goal of combination therapy is to reduce …

The evolution of drug resistance in HIV occurs by the fixation of specific, well-known, drug-resistance
mutations, but the underlying population genetic processes are not well understood…

Evolutionary theory has produced two conflicting paradigms for the adaptation of a polygenic
trait. While population genetics views adaptation as a sequence of selective sweeps at …

Active-learning pedagogies have been repeatedly demonstrated to produce superior
learning gains with large effect sizes compared with lecture-based pedagogies. Shifting large …

Many efforts to improve science teaching in higher education focus on a few faculty members
at an institution at a time, with limited published evidence on attempts to engage faculty …