We have developed a sensitive, accurate, and multiplexed microRNA (miRNA) profiling
assay that is based on a highly efficient labeling method and novel microarray probe design. …

Unlike mammalian and yeast cells, little is known about how plants regulate G 1 progression
and entry into the S phase of the cell cycle. In mammalian cells, a key regulator of this …

Prader–Willi syndrome (PWS) and Angelman syndrome (AS) are oppositely imprinted
autism-spectrum disorders with known genetic bases, but complex epigenetic mechanisms …

Background Determining the expression levels of microRNAs (miRNAs) is of great interest
to researchers in many areas of biology, given the significant roles these molecules play in …

Prader–Willi syndrome (PWS), a genetic disorder of obesity, intellectual disability and sleep
abnormalities, is caused by loss of non-coding RNAs on paternal chromosome 15q11-q13. …

In mammalian cells, the retinoblastoma (RB) protein regulates G1 progression and functions
through its association with various cellular proteins. Two closely related mammalian RB …

The discovery of complex structural variations that exist within individual genomes has
prompted a need to visualize chromosomes at a higher resolution than previously possible. To …

Ran is a 25-kDa Ras-related nuclear GTP-binding protein which is very highly conserved in
humans, Saccharomyces cerevisiae, and Schizosaccharomyces pombe. Ran has been …

Non-random, dynamic three-dimensional organization of the nucleus is important for
regulation of gene expression. Numerous studies using chromosome conformation capture …

Three-dimensional (3D) genome organization is thought to be important for regulation of gene
expression. Chromosome conformation capture-based studies have uncovered ensemble …