Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamases
which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are …

Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in
1996. Since then, these versatile β-lactamases have spread internationally among Gram-…

We may soon be facing the end of the “antibiotic era.” The initial and seemingly unstoppable
success of antibiotics, the fruit of human ingenuity, has been countered by an escalation of …

In this review, we summarize the current “state of the art” of carbapenem antibiotics and
their role in our antimicrobial armamentarium. Among the β-lactams currently available, …

Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance
to antibiotics and for their ability to acquire genes encoding resistance determinants. …

The Infectious Diseases Society of America (IDSA) is committed to providing up-to-date
guidance on the treatment of antimicrobial-resistant infections. A previous guidance document …

Background Colonization and infection with vancomycin-resistant enterococci have been
associated with exposure to antibiotics that are active against anaerobes. In mice that have …

Acinetobacter is a complex genus, and historically, there has been confusion about the
existence of multiple species. The species commonly cause nosocomial infections, …

Background Antimicrobial-resistant infections are commonly encountered in US hospitals
and result in significant morbidity and mortality. This guidance document provides …