[HTML][HTML] Genetic variation and RNA structure regulate microRNA biogenesis
N Fernandez, RA Cordiner, RS Young, N Hug… - Nature …, 2017 - nature.com
MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of
sequence and secondary RNA structure in this process has not been extensively studied. A …
sequence and secondary RNA structure in this process has not been extensively studied. A …
[PDF][PDF] Rapid depletion of DIS3, EXOSC10, or XRN2 reveals the immediate impact of exoribonucleolysis on nuclear RNA metabolism and transcriptional control
L Davidson, L Francis, RA Cordiner, JD Eaton, C Estell… - Cell reports, 2019 - cell.com
Cell-based studies of human ribonucleases traditionally rely on methods that deplete proteins
slowly. We engineered cells in which the 3′→5′ exoribonucleases of the exosome …
slowly. We engineered cells in which the 3′→5′ exoribonucleases of the exosome …
[PDF][PDF] DGCR8 acts as an adaptor for the exosome complex to degrade double-stranded structured RNAs
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis
but also binds and regulates the stability of several types of cellular RNAs. Of particular …
but also binds and regulates the stability of several types of cellular RNAs. Of particular …
Cellular functions of the microprocessor
S Macias, RA Cordiner… - Biochemical Society …, 2013 - portlandpress.com
The microprocessor is a complex comprising the RNase III enzyme Drosha and the double-stranded
RNA-binding protein DGCR8 (DiGeorge syndrome critical region 8 gene) that …
RNA-binding protein DGCR8 (DiGeorge syndrome critical region 8 gene) that …
[HTML][HTML] Temporal-iCLIP captures co-transcriptional RNA-protein interactions
Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA polymerase
II (RNAPII)-derived transcripts. Yet, our current understanding of this process in vivo …
II (RNAPII)-derived transcripts. Yet, our current understanding of this process in vivo …
Monitoring protein-RNA interaction dynamics in vivo at high temporal resolution using χCRAC
…, I Ivanova, RW van Nues, RA Cordiner… - JoVE (Journal of …, 2020 - jove.com
The interaction between RNA-binding proteins (RBPs) and their RNA substrates exhibits
fluidity and complexity. Within its lifespan, a single RNA can be bound by many different RBPs …
fluidity and complexity. Within its lifespan, a single RNA can be bound by many different RBPs …
Purification of Microprocessor-associated factors
RA Cordiner, S Macias - miRNA Biogenesis: Methods and Protocols, 2018 - Springer
The Microprocessor complex catalyzes the first step of miRNA biogenesis in the nucleus of
mammalian cells. The minimal catalytically active complex is formed by two essential factors, …
mammalian cells. The minimal catalytically active complex is formed by two essential factors, …
[CITATION][C] Supplemental Information DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs
S Macias, RA Cordiner, P Gautier, M Plass, JF Cáceres
[CITATION][C] Genetic variation and RNA structure regulate microRNA biogenesis. Nat Commun. 2017; 8: 15114
N Fernandez, RA Cordiner, RS Young, N Hug…
[CITATION][C] Cá ceres, JF, and West, S.(2019). Rapid depletion of DIS3, EXOSC10, or XRN2 reveals the immediate impact of exoribonucleolysis on nuclear RNA …
L Davidson, L Francis, RA Cordiner, JD Eaton, C Estell…