User profiles for R. C. Spitale
Robert SpitaleVerified email at uci.edu Cited by 8212 |
Long intergenic noncoding RNAs: new links in cancer progression
MC Tsai, RC Spitale, HY Chang - Cancer research, 2011 - AACR
The process of cancer metastasis involves a series of sequential and complex steps. Here
we give a perspective on recent results regarding noncoding transcription in cancer …
we give a perspective on recent results regarding noncoding transcription in cancer …
Understanding the transcriptome through RNA structure
RNA structure is crucial for gene regulation and function. In the past, transcriptomes have
largely been parsed by primary sequences and expression levels, but it is now becoming …
largely been parsed by primary sequences and expression levels, but it is now becoming …
[HTML][HTML] Probing the dynamic RNA structurome and its functions
RC Spitale, D Incarnato - Nature Reviews Genetics, 2023 - nature.com
RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high-…
molecules are thought to be central to their functions. The recent fast-paced evolution of high-…
Control of somatic tissue differentiation by the long non-coding RNA TINCR
…, AF Groff, J Chow, D Johnston, GE Kim, RC Spitale… - Nature, 2013 - nature.com
Several of the thousands of human long non-coding RNAs (lncRNAs) have been
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …
functionally characterized 1 , 2 , 3 , 4 ; however, potential roles for lncRNAs in somatic tissue …
Structural imprints in vivo decode RNA regulatory mechanisms
Visualizing the physical basis for molecular behaviour inside living cells is a great challenge
for biology. RNAs are central to biological regulation, and the ability of RNA to adopt …
for biology. RNAs are central to biological regulation, and the ability of RNA to adopt …
Landscape and variation of RNA secondary structure across the human transcriptome
In parallel to the genetic code for protein synthesis, a second layer of information is embedded
in all RNA transcripts in the form of RNA structure. RNA structure influences practically …
in all RNA transcripts in the form of RNA structure. RNA structure influences practically …
RNA SHAPE analysis in living cells
RC Spitale, P Crisalli, RA Flynn, EA Torre… - Nature chemical …, 2013 - nature.com
RNA structure has important roles in practically every facet of gene regulation, but the paucity
of in vivo structural probes limits current understanding. Here we design, synthesize and …
of in vivo structural probes limits current understanding. Here we design, synthesize and …
A biologically stable DNAzyme that efficiently silences gene expression in cells
Y Wang, K Nguyen, RC Spitale, JC Chaput - Nature Chemistry, 2021 - nature.com
Efforts to use RNA-cleaving DNA enzymes (DNAzymes) as gene-silencing agents in therapeutic
applications have stalled due to their low efficacy in clinical trials. Here we report a xeno…
applications have stalled due to their low efficacy in clinical trials. Here we report a xeno…
RNA helicase DDX21 coordinates transcription and ribosomal RNA processing
DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle
1 , but the molecular underpinnings of their involvement, particularly in mammalian cells, …
1 , but the molecular underpinnings of their involvement, particularly in mammalian cells, …
[HTML][HTML] Molecular targets of aspirin and cancer prevention
L Alfonso, G Ai, RC Spitale, GJ Bhat - British journal of cancer, 2014 - nature.com
Salicylates from plant sources have been used for centuries by different cultures to treat a
variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic acid, …
variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic acid, …