Purpose We review recent advances in the biologic understanding and treatment of
childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), identify …

For cytotoxic agents to have an effect on tumor cells, drugs must first be transported into the
cell, potentially be metabolized to an active form, and interact appropriately with target …

Langerhans cell histiocytosis (LCH) is a rare disease of the monocyte-macrophage system.
The clinical presentation ranges from a single bone lesion to widespread multiorgan …

We report the cDNA cloning and characterization of mouse GATA-4, a new member of the
family of zinc finger transcription factors that bind a core GATA motif. GATA-4 cDNA was …

The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a
member of a multigene family. We have identified distinct mdr gene transcripts encoded by …

The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent
extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. …

The development of arteriosclerotic lesions in the Lewis to F344 rat model of chronic cardiac
rejection is characterized by macrophage adhesion to the vessel lumen and macrophage …

Background Discovery that the transcriptional output of the human genome is far more
complex than predicted by the current set of protein-coding annotations and that most RNAs …

CCG-2961 incorporated 3 new agents, idarubicin, fludarabine and interleukin-2, into a
phase 3 AML trial using intensive-timing remission induction/consolidation and related donor …

… Arceci … Arceci, Stewart Goldman, Timothy Griffin, Arnold Altman, Bruce Gordon, Laurel
Steinherz, Steven Weitman, Peter Steinherz Data analysis and interpretation: Sima Jeha …