In the current data-rich era, making the leap from sequence data to knowledge is a task that
requires an elegant bioinformatics toolset to pinpoint pressing research questions. Therefore…

The ADP-ribosyltransferases are a class of enzymes that display activity in a variety of
bacterial pathogens responsible for causing diseases in plants and animals, including those …

C3larvin toxin was identified by a bioinformatic strategy as a putative mono-ADP-ribosyltransferase
and a possible virulence factor from Paenibacillus larvae, which is the causative …

Chelt, a cholera-like toxin from Vibrio cholerae, and Certhrax, an anthrax-like toxin from
Bacillus cereus, are among six new bacterial protein toxins we identified and characterized …

Photorhabdus luminescens is a pathogenic bacterium that produces many toxic proteins.
The mono-ADP-ribosyltransferases (mARTs) are an enzyme class produced by numerous …

Heteropolymeric B‐band O‐antigen (O‐Ag) biosynthesis in Pseudomonas aeruginosa
PAO1 follows the Wzy‐dependent pathway, beginning with translocation of undecaprenyl …

The mono-ADP-ribosyltransferase toxins are bacterial virulence factors that contribute to
many disease states in plants, animals, and humans. These toxins function as enzymes that …

Recently developed maximum entropy methods infer evolutionary constraints on protein
function and structure from the millions of protein sequences available in genomic databases. …

The emergence of bacterial antibiotic resistance poses a significant challenge in the pursuit
of novel therapeutics, making new strategies for drug discovery imperative. We have …

Certain Vibrio cholerae strains produce cholix, a potent protein toxin that has diphthamide-specific
ADP-ribosyltransferase activity against eukaryotic elongation factor 2. Here we …