Little is known about the optimal duration of therapy with an anti–tumor necrosis factor (TNF)
agent and/or an immunomodulator for patients with inflammatory bowel disease (IBD). We …

Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their shared
common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger signal …

Endogenous damage-associated molecular patterns (DAMPs) are released during tissue
damage and have increasingly recognized roles in the etiology of many human diseases. The …

Background & Aims Preclinical ulcerative colitis is poorly defined. We aimed to characterize
the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of …

… Specific author contributions: Study design: RK and JS Patient recruitment and sample
processing: NTV, RK, NAK, and RKB Experimental work: RK and MRV Data analysis: RK, NAK, …

Background Due to common evolutionary origins, mitochondrial DNA (mtDNA) shares many
similarities with immunogenic bacterial DNA. MtDNA is recognized as a pro-inflammatory …

Crohn’s disease and ulcerative colitis are increasingly prevalent, relapsing and remitting
inflammatory bowel diseases (IBDs) with variable disease courses and complications. Their …

The multidrug resistance-1 (MDR1) gene encodes an ATP-dependent efflux transporter that
is highly expressed in the colon. In mice, loss of MDR1 function results in colitis with …

Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's
disease - Boyapati, RK - 2018 | Cochrane Library … Ray K Boyapati …

… Boyapati and Gwo-tzer Ho; performed literature search and contributed to the writing of the
manuscript: Ray K. Boyapati; … Jostins L, Ripke S, Weersma RK et al. Host-microbe interactions …