The biological function of plant mitochondrial uncoupling proteins (pUCPs) has been a matter
of considerable controversy. For example, the pUCP capacity to uncouple respiration from …

Cadmium is a transition metal ion that is highly toxic in biological systems. Although relatively
rare in the Earth’s crust, anthropogenic release of cadmium since industrialization has …

β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis,
and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP …

CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked
with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe …

Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual
AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1…

The relative stability of divalent first-row transition metal ion complexes, as defined by the
Irving-Williams series, poses a fundamental chemical challenge for selectivity in bacterial metal …

Background The B3 DNA binding domain includes five families: auxin response factor (ARF),
abscisic acid-insensitive3 (ABI3), high level expression of sugar inducible (HSI), related to …

Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help
unravel the complexities of kinase signaling. As the biological functions of individual kinases …

The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1,
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …

S treptococcus pneumoniae is a globally significant human pathogen responsible for nearly
1 million deaths annually. Central to the ability of S . pneumoniae to colonize and mediate …