Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia
and now poses a threat to the control and elimination of malaria. Mapping the geographic …

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the global
malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc…

We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, …

Background Artemisinin resistance in Plasmodium falciparum lengthens parasite clearance
half-life during artemisinin monotherapy or artemisinin-based combination therapy. Absence …

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

Background Artemisinin resistance in Plasmodium falciparum threatens to reduce the efficacy
of artemisinin combination therapies (ACTs), thus compromising global efforts to eliminate …

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated with …

Background Artemisinin-resistant Plasmodium falciparum has been reported in Pailin,
western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of this …

Background As the prevalence of artemisinin-resistant Plasmodium falciparum malaria
increases in the Greater Mekong subregion, emerging resistance to partner drugs in artemisinin …