Active efflux of antimicrobial agents is a primary mechanism by which bacterial pathogens
can become multidrug resistant. The combined use of efflux pump inhibitors (EPIs) with pump …

Background Estimates of relationships among Staphylococcus species have been hampered
by poor and inconsistent resolution of phylogenies based largely on single gene analyses …

The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of nosocomial
infections. Its relatively impermeable outer membrane ( OM ) limits antibiotic entry, and a …

Background Staphylococcus aureus (SA) nasal colonization plays a critical role in the
pathogenesis of staphylococcal infections and SA eradication from the nares has proven to be …

Pseudomonas aeruginosa is a leading cause of hospital-acquired infections and is resistant
to many antibiotics. Among its primary mechanisms of resistance is expression of a …

Due to the increasing prevalence of nosocomial and community-acquired antibiotic resistant
Staphylococcus aureus (SA), understanding the determinants of SA nasal carriage has …

Nasal carriage of Staphylococcus aureus has long been hypothesized to be a major vector
for the transmission of virulent strains throughout the community. To address this hypothesis, …

Type IVa pili (T4aP) function as bacterial virulence factors. T4aP pass through the outer
membranes of Gram-negative bacteria via homo-oligomeric secretins. We present a 7.4 Å …

Type IVa pili (T4aP) are ubiquitous microbial appendages used for adherence, twitching
motility, DNA uptake, and electron transfer. Many of these functions depend on dynamic …

Several design models of centrifugal pump impellers were tested in water to determine tip-clearance
effects on noncavitating and cavitating performance. Although most of these …