Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

The pattern of neurotransmitter pathway losses in Alzheimer's disease are reviewed. Deficits
of the cholinergic pathway from the nucleus basalis, the noradrenergic pathway from the …

The post-mortem brain concentrations of dopamine (DA) and homo-vanillic acid (HVA) were
determined in 16 parts of the brain from patients with no history of neurologic or psychiatric …

Individual differences in cognitive performance increase with advancing age, reflecting
marked cognitive changes in some individuals along with little or no change in others. Genetic …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons.
We recently reported that reduced expression of Vegfa causes ALS-like motoneuron …

This prospective study was designed to examine the contributions of neurobiological,
functional, and psychosocial factors to major depression after stroke. In addition, the prevalence …

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL),
also known as "Nasu-Hakola disease," is a globally distributed recessively inherited disease …

BACKGROUND: Bipolar disorders (BP) are frequently diagnosed and treated as pure depression
initially; accurate diagnosis often being delayed by 8 to 10 years. In prospective studies…

The objective of this article is to present an overview of a prospective cohort study involving
a total of 3,000 subjects whose ages were 35, 40, 45, 50, 55, 60, 65, 70, 75, and 80 years …