User profiles for R. Beroukhim
Rameen BeroukhimDana-Farber Cancer Institute, Harvard Medical School Verified email at broadinstitute.org Cited by 171966 |
Genomic evolution of cancer models: perils and opportunities
Cancer research relies on model systems, which reflect the biology of actual human tumours
to only a certain extent. One important feature of human cancer is its intra-tumour genomic …
to only a certain extent. One important feature of human cancer is its intra-tumour genomic …
Medical therapies for meningiomas
Meningiomas are the most common primary brain tumor in adults. Although the majority of
these tumors can be effectively treated with surgery and radiation therapy, an important …
these tumors can be effectively treated with surgery and radiation therapy, an important …
[HTML][HTML] The somatic genomic landscape of glioblastoma
We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …
The landscape of somatic copy-number alteration across human cancers
R Beroukhim, CH Mermel, D Porter, G Wei… - Nature, 2010 - nature.com
A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
[PDF][PDF] Genomic classification of cutaneous melanoma
…, D Belyaev, C Benz, B Bernard, R Beroukhim… - Cell, 2015 - cell.com
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
[PDF][PDF] The molecular taxonomy of primary prostate cancer
… R. Beroukhim is a consultant for and received grant funding from Novartis. M. Meyerson
received research support from Bayer and has equity in and is a consultant for Foundation …
received research support from Bayer and has equity in and is a consultant for Foundation …
[PDF][PDF] Integrated genomic characterization of papillary thyroid carcinoma
…, S Balu, SB Baylin, M Behera, B Bernard, R Beroukhim… - Cell, 2014 - cell.com
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
…, N Thiessen, K Tse, T Wong, AC Berger, R Beroukhim… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
Structural variations in cancer and the 3D genome
Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …
genetic alteration but difficulties in detecting and interpreting them have limited our …
[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
…, N Thiessen, K Tse, T Wong, AC Berger, R Beroukhim… - Cell, 2018 - cell.com
… dichotomized the data using a b-value of R 0.3 to define positive DNA methylation and < 0.3
… CpG sites that were methylated at a b-value of R 0.3 in more than 10% of tumors within any …
… CpG sites that were methylated at a b-value of R 0.3 in more than 10% of tumors within any …