Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence
of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen peroxide…

Caenorhabditis elegans exhibits a repertoire of behaviors that can be studied by genetic,
anatomical and pharmacological approaches. Defecation is one of the simpler behaviors, …

Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is
well established that extrasynaptic volume transmission, especially via monoamines and …

… ,(11) as well as numerous other mutations that we have identified in a screen aimed at
identifying suppressors of clk-1 (R. Branicky, J. Feng, and S. Hekimi, unpublished observations). …

In vitro studies have indicated that reactive oxygen species (ROS) and the oxidation of
signaling molecules are important mediators of signal transduction. We have identified two …

… (A) As the number of template postures increases, the R 2 of the fit between original body …
rate of increase in R 2 for increasing k. The red dashed line is the average increase in R 2 per …

Metabolic flexibility is an essential characteristic of eukaryotic cells in order to adapt to
physiological and environmental changes. Especially in mammalian cells, the metabolic switch …

Although undulatory swimming is observed in many organisms, the neuromuscular basis for
undulatory movement patterns is not well understood. To better understand the basis for the …

The development of neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington
disease is strongly age-dependent. Discovering drugs that act on the high rate of aging …

We show that elevation of mitochondrial superoxide generation increases Caenorhabditis
elegans life span by enhancing a RAS-dependent ROS (reactive oxygen species) signaling …