Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …

Key questions regarding the molecular nature of prions are how different prion strains can
be propagated by the same protein and whether they are only protein 1 , 2 , 3 . Here we …

The physiology of N-methyl-d-aspartate (NMDA) receptors is fundamental to brain
development and function. NMDA receptors are ionotropic glutamate receptors that function as …

Filopodia are cell surface protrusions that are essential for cell migration. This finger-like
structure is supported by rigid tightly bundled actin filaments. The protein responsible for actin …

The nuclear pore complex (NPC) is a multiprotein assembly that serves as the sole mediator
of nucleocytoplasmic exchange in eukaryotic cells. In this paper, we use an integrative …

… Carlos Diaz-Avalos for help with the statistical analysis of the data. This work was supported
by National Institutes of Health Grant NS24442 (to RD-A.) and a National Institutes of Health …

10.7554/eLife.28560.001 In bacteria, mRNA transcription and translation are coupled to
coordinate optimal gene expression and maintain genome stability. Coupling is thought to …

Developing potent therapeutics and effective vaccines are the ultimate goals in controlling
infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects …

The seven-residue peptide GNNQQNY from the N-terminal region of the yeast prion protein
Sup35, which forms amyloid fibers, colloidal aggregates and highly ordered nanocrystals, …

To elucidate the structural basis of the mechanism of microtubule depolymerization by
kinesin-13s, we analyzed complexes of tubulin and the Drosophila melanogaster kinesin-13 …