User profiles for R. Freathy
 | Rachel M FreathyUniversity of Exeter Verified email at exeter.ac.uk Cited by 24490 |
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
Common variants near MC4R are associated with fat mass, weight and risk of obesity
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
Genome-wide association analysis identifies 20 loci that influence adult height
Adult height is a model polygenic trait, but there has been limited success in identifying the
genes underlying its normal variation. To identify genetic variants influencing adult human …
genes underlying its normal variation. To identify genetic variants influencing adult human …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
…, B Widmer, JA Todd, TM Frayling, RM Freathy… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …
to more common diseases than any other region of the human genome, including almost …
[HTML][HTML] Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Being a morning person is a behavioural indicator of a person’s underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we …
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we …
A common variant of HMGA2 is associated with adult and childhood height in the general population
Human height is a classic, highly heritable quantitative trait. To begin to identify genetic variants
influencing height, we examined genome-wide association data from 4,921 individuals. …
influencing height, we examined genome-wide association data from 4,921 individuals. …
Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
RM Freathy, NJ Timpson, DA Lawlor, A Pouta… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Common variation in the FTO gene is associated with BMI and type 2 diabetes.
Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, …
Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, …
[HTML][HTML] Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci
Disrupted circadian rhythms and reduced sleep duration are associated with several human
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …