Leukocyte counts based on DNA methylation at individual cytosines

…, M Lenz, P Uciechowski, Y Han, R Herwartz… - Clinical …, 2018 - academic.oup.com
… Here, C R and C G resemble the copy number of the … the reference plasmids (C R ), we
used the following formula: … correlation for monocytes (r = 0.60) and lymphocytes (r = 0.61) was …

Circular anchors for the detection of hematopoietic cells using retinanet

…, Ö Özkan, M Crysandt, R Herwartz… - 2020 IEEE 17th …, 2020 - ieeexplore.ieee.org
… This removes the need for a second stage employed by the more complex architectures
Faster R-CNN [9] and Mask R-CNN [10]. RetinaNet’s network architecture uses a Feature …

Evaluating out-of-the-box methods for the classification of hematopoietic cells in images of stained bone marrow

P Gräbel, M Crysandt, R Herwartz, M Hoffmann… - … and Ophthalmic Medical …, 2018 - Springer
Compared to the analysis of blood cells in microscope images of peripheral blood, bone
marrow images are much more challenging for automated cell classification: not only are the …

[HTML][HTML] Bone marrow biopsy in geriatric patients above the age of 85 years: invaluable or unnecessary? A retrospective analysis

KD Zhang, E Jost, J Panse, R Herwartz… - Annals of …, 2024 - Springer
Bone marrow biopsy (BMB) is a well-established diagnostic tool for various hematological,
oncological, and other medical conditions. However, treatment options for geriatric patients (…

svars: An R package for data-driven identification in multivariate time series analysis

A Lange, B Dalheimer, H Herwartz… - Journal of Statistical …, 2021 - jstatsoft.org
… We describe the R package svars which implements statistical identification techniques that
… provide a detailed description of the associated R functions. Furthermore, a macroeconomic …

[HTML][HTML] State of the art cell detection in bone marrow whole slide images

P Gräbel, Ö Özkan, M Crysandt, R Herwartz… - Journal of Pathology …, 2021 - Elsevier
… This analysis compares the three detection networks Mask R-CNN, RetinaNet, and Yolo v3
as well as U-Net based detection and the RetinaNet with circular anchors (Circular RetinaNet…

Cup‐like blasts in acute myeloid leukemia

E Jost, R Herwartz, M Hoß, L Vankann… - American Journal of …, 2015 - Wiley Online Library
A patient with AML with normal karyotype and the cytological pattern of cup‐like blasts (CLB)
is reported. The typical morphology on Pappenheim stained blood smears is shown. In …

Systematic analysis and automated search of hyper-parameters for cell classifier training

…, G Nickel, M Crysandt, R Herwartz… - 2020 IEEE 17th …, 2020 - ieeexplore.ieee.org
Performance and robustness of neural networks depend on a suitable choice of hyper-parameters,
which is important in research as well as for the final deployment of deep learning …

Refinement of weak annotations for the segmentation of bone marrow leukocytes

P Gräbel, M Crysandt, R Herwartz… - MICCAI 2019 …, 2019 - openreview.net
Deep neural networks are well suited to address medical problems such as the automated
analysis of leukocytes in bone marrow images. However, their training requires large …

Leukocyte counts based on site-specific DNA methylation analysis

…, T Božić, M Lenz, P Uciechowski, Y Han, R Herwartz… - bioRxiv, 2017 - biorxiv.org
… To determine the copy number of the reference plasmids (C R ) we used the following formula:
Embedded Image where m R is the added reference amount (eg 0.011 ng of LSM14B), N …