Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …

Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …

Proper synaptic pruning is essential for the development of functional neural circuits.
Impairments in synaptic pruning disrupt the excitatory versus inhibitory balance (E/I balance) of …

Background Dual blockade of the EGFR and VEGF pathways in EGFR-mutated metastatic
non-small-cell lung cancer (NSCLC) is supported by preclinical and clinical data, yet the …

The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in sporadic and
familial colorectal tumours 1 , 2 , 3 . APC is involved in the proteasome-mediated …

The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis
and in sporadic colorectal tumors. Here the APC gene product is shown to bind through its …

… SPARC, was not significantly affected by a single bout of exercise, and resting state and
post-exercise change ratios of SPARC concentration and platelet counts were not correlated (R …

Many diseases, especially cancers, result from aberrant or overexpression of pathogenic
proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, …

Neuroligin (NLG), a postsynaptic adhesion molecule, is involved in the formation of synapses
by binding to a cognate presynaptic ligand, neurexin. Here we report that neuroligin-1 (…