A computational algebra approach to the reverse engineering of gene regulatory networks

R Laubenbacher, B Stigler - Journal of theoretical biology, 2004 - Elsevier
… 63): f i 0 ( x )= ∑ j=1 m−1 s j+1,i r j ( x ), where x =(x 1 ,…,x n ) and the polynomials r j are … l
−s k,l ) for every j≠k and set r j ( x )= ∏ k=1 m−1 b jk ( x ). We note that r j ( s j )=1 and r j ( x )=0 …

Foundations of a connectivity theory for simplicial complexes

H Barcelo, X Kramer, R Laubenbacher… - Advances in Applied …, 2001 - Elsevier
… As part of a research project on decision networks, Kramer and Laubenbacher, following
suggestions in Atkin’s papers, began developing a general connectivity theory of simplicial …

[BOOK][B] Mathematical expeditions: Chronicles by the explorers

R Laubenbacher, D Pengelley - 2013 - books.google.com
This book contains the stories of five mathematical journeys into new realms, told through
the writings of the explorers themselves. Some were guided by mere curiosity and the thrill of …

Boolean nested canalizing functions: A comprehensive analysis

…, D Murrugarra, B Aguilar, R Laubenbacher - Theoretical Computer …, 2013 - Elsevier
… (4.1) and the number r is uniquely determined by f , we can make the following definition. …
Let NCF(n,r) denote the set of all nested canalizing functions in n variables with layer number r, …

[HTML][HTML] Topological data analysis in biomedicine: A review

Y Skaf, R Laubenbacher - Journal of Biomedical Informatics, 2022 - Elsevier
… Author links open overlay panel Yara Skaf a b , Reinhard Laubenbacher a b … The lensed
space is frequently chosen to be Z = R , meaning the lens simply associates a value to each …

A systems biology approach to iron metabolism

J Chifman, R Laubenbacher, SV Torti - A Systems Biology Approach to …, 2014 - Springer
Iron is critical to the survival of almost all living organisms. However, inappropriately low or
high levels of iron are detrimental and contribute to a wide range of diseases. Recent …

[HTML][HTML] Building digital twins of the human immune system: toward a roadmap

R Laubenbacher, A Niarakis, T Helikar, G An… - NPJ digital …, 2022 - nature.com
Digital twins, customized simulation models pioneered in industry, are beginning to be deployed
in medicine and healthcare, with some major successes, for instance in cardiovascular …

Using digital twins in viral infection

R Laubenbacher, JP Sluka, JA Glazier - Science, 2021 - science.org
When the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic emerged
in 2019, researchers rapidly recalibrated epidemiological computer models originally …

[HTML][HTML] Bioinformatics tools for cancer metabolomics

G Blekherman, R Laubenbacher, DF Cortes, P Mendes… - Metabolomics, 2011 - Springer
It is well known that significant metabolic change take place as cells are transformed from
normal to malignant. This review focuses on the use of different bioinformatics tools in cancer …

A systems biology view of cancer

R Laubenbacher, V Hower, A Jarrah, SV Torti… - … et Biophysica Acta (BBA …, 2009 - Elsevier
In order to understand how a cancer cell is functionally different from a normal cell it is
necessary to assess the complex network of pathways involving gene regulation, signaling, and …