Proton transfer in catalysis and the role of proton shuttles in carbonic anhydrase

RL Mikulski, DN Silverman - Biochimica et Biophysica Acta (BBA)-Proteins …, 2010 - Elsevier
The undisputed role of His64 in proton transfer during catalysis by carbonic anhydrases in
the α class has raised questions concerning the details of its mechanism. The highly …

[PDF][PDF] Continuity and admixture in the last five millennia of Levantine history from ancient Canaanite and present-day Lebanese genome sequences

…, E Matisoo-Smith, H Schutkowski, R Mikulski… - The American Journal of …, 2017 - cell.com
… the Lebanese (r ¼ 0.74; 95% CI ¼ 0.63–0.82; p value ¼ 8.168 3 10 À16 ) and lower correlations
between Sidon_BA and Europeans (r ¼ 0.56), Africans (r ¼ 0.55), and Asians (r ¼ 0.53) …

Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation

P Quint, R Reutzel, R Mikulski, R McKenna… - Free Radical Biology …, 2006 - Elsevier
… unmodified human MnSOD had an R cryst of 21.7 % (R free of 24.0 %) with an average B
factor of 26.2 Å 2 ; and the nitrated human MnSOD had an R cryst of 19.7% (R free of 21.8 %) …

The Black Death cemetery, East Smithfield, London

I Grainger, D Hawkins, L Cowal, R Mikulski - [""], 2008 - mola.iro.bl.uk
The East Smithfield Black Death cemetery was excavated in 1986–8 as part of the Royal Mint
site. Founded in 1348/9, it was one of two emergency burial grounds established when the …

Water networks in fast proton transfer during catalysis by human carbonic anhydrase II

R Mikulski, D West, KH Sippel, BS Avvaru… - Biochemistry, 2013 - ACS Publications
… The 18 O exchange rate for proton transfer, R H 2 O , from which we obtain k B is determined
at chemical equilibrium and focuses more on proton transfer because it contains many …

[PDF][PDF] A transient pulse of genetic admixture from the crusaders in the near east identified from ancient genome sequences

…, CL Scheib, Y Xue, R Mikulski, R Martiniano… - The American Journal of …, 2019 - cell.com
During the medieval period, hundreds of thousands of Europeans migrated to the Near East
to take part in the Crusades, and many of them settled in the newly established Christian …

2-Substituted 4, 5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases

P Chen, LB Horton, RL Mikulski, L Deng… - Bioorganic & medicinal …, 2012 - Elsevier
Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL),
especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat …

Sound absorption performance of a labyrinthine metamaterial with arbitrary cross-sectional microperforations

…, LR Barbosa, A Lenzi, I Cassettari, RZ Mikulski - Journal of the Brazilian …, 2023 - Springer
Studies on acoustic metamaterials (AMM) with coiled spaces as a solution for low-medium
frequency sound absorption are regularly presented. However, the influence of panel …

Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-β-lactamase active site

LB Horton, S Shanker, R Mikulski… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Metallo-β-lactamases catalyze the hydrolysis of a broad range of β-lactam antibiotics and
are a concern for the spread of drug resistance. To analyze the determinants of enzyme …

[HTML][HTML] Generation and Characterization of Antibodies against Asian Elephant (Elephas maximus) IgG, IgM, and IgA

…, RS Peng, SM Benton, X Qin, KC Worley, RL Mikulski… - PLoS …, 2015 - journals.plos.org
Asian elephant (Elephas maximus) immunity is poorly characterized and understood. This
gap in knowledge is particularly concerning as Asian elephants are an endangered species …