User profiles for R. Swofford

Ross Swofford

Computational Scientist, Broad Institute
Verified email at broadinstitute.org
Cited by 6227

[HTML][HTML] The genomic basis of adaptive evolution in threespine sticklebacks

…, YF Chan, P Russell, E Mauceli, J Johnson, R Swofford… - Nature, 2012 - nature.com
Marine stickleback fish have colonized and adapted to thousands of streams and lakes
formed since the last ice age, providing an exceptional opportunity to characterize genomic …

[HTML][HTML] The genomic substrate for adaptive radiation in African cichlid fish

…, ME Santos, S Searle, T Sharpe, R Swofford… - Nature, 2014 - nature.com
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great
Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic …

[HTML][HTML] The genome of the green anole lizard and a comparative analysis with birds and mammals

…, T Sanger, S Searle, JD Smith, Z Smith, R Swofford… - Nature, 2011 - nature.com
The evolution of the amniotic egg was one of the great evolutionary innovations in the history
of life, freeing vertebrates from an obligatory connection to water and thus permitting the …

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

…, H Zhao, DP Genereux, R Swofford… - Proceedings of the …, 2020 - National Acad Sciences
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 …

Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

…, RL Rabin, J Arthos, A Rubbert, M Dybul, R Swofford… - Nature, 1997 - nature.com
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) enter target
cells by forming a complex between the viral envelope protein and two cell-surface …

Evolutionary constraint and innovation across hundreds of placental mammals

…, LR Moreira, RW Redlich, L Ryan, R Swofford… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Ancestry-inclusive dog genomics challenges popular breed stereotypes

…, M Koltookian, C Lieu, K Megquier, R Swofford… - Science, 2022 - science.org
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling

RL Rabin, MK Park, F Liao, R Swofford… - The Journal of …, 1999 - journals.aai.org
To address the issues of redundancy and specificity of chemokines and their receptors in
lymphocyte biology, we investigated the expression of CC chemokine receptors CCR1, CCR2, …

[HTML][HTML] An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts

…, G Sundström, A Cook, MG FitzGerald, R Swofford… - PloS one, 2014 - journals.plos.org
The domestic dog, Canis familiaris, is a well-established model system for mapping trait and
disease loci. While the original draft sequence was of good quality, gaps were abundant …

Thermal lens technique: a new method of absorption spectroscopy

ME Long, RL Swofford, AC Albrecht - Science, 1976 - science.org
Both a single beam and a dual beam (with synchronous detection) thermal lens technique
have been employed in the measurement of "colorless" organic compounds in the range …