Acute lateral ankle ligament sprains are common in young athletes (15 to 35 years of age).
Diagnostic and treatment protocols vary. Therapies range from cast immobilisation or acute …

Background Osteoarthritis (OA) refers to a heterogeneous group of conditions that lead to
joint symptoms and signs associated with loss of integrity of the articular cartilage, in …

Acute ankle ligament sprains are common injuries. The majority of these occur during athletic
participation in the 15 to 35 year age range. Despite the frequency of the injury, diagnostic …

Background. Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment
is often limited by side effects related to the drug's many pharmacologic actions. Selective …

We performed sensory assessments before and during diagnostic tourniquet-cuff and local
anesthetic blocks in 4 patients diagnosed with reflex sympathetic dystrophy (RSD). All …

Aicardi-Goutières syndrome (AGS) presents as a severe neurological brain disease and is
a genetic mimic of the sequelae of transplacentally acquired viral infection 1 , 2 . Evidence …

Aicardi-Goutières syndrome (AGS) is a genetic encephalopathy whose clinical features mimic
those of acquired in utero viral infection. AGS exhibits locus heterogeneity, with mutations …

A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child
with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia. Subsequent SOX2 mutation …

Improvements in DNA synthesis and sequencing have underpinned comprehensive
assessment of gene function in bacteria and eukaryotes. Genome-wide analyses require high-…

Many genetic diseases have been linked to the dysfunction of primary cilia, which occur nearly
ubiquitously in the body and act as solitary cellular mechanosensory organelles. The list …