Regulatory T cells (Tregs) constitute an attractive therapeutic target given their essential role
in controlling autoimmunity. However, recent animal studies provide evidence for functional …

We performed whole-genome sequencing (WGS) of 208 genomes from 53 families affected
by simplex autism. For the majority of these families, no copy-number variant (CNV) or …

Regulatory T cells (Tregs) play a central role in counteracting inflammation and autoimmunity.
A more complete understanding of cellular heterogeneity and the potential for lineage …

Background Therapies directed at augmenting regulatory T cell (Treg) activities in vivo as a
systemic treatment for autoimmune disorders and transplantation may be associated with …

Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–2%)
1 , 2 – 3 that frequently presents with ascending aortic aneurysm (AscAA) 4 . BAV/AscAA …

Imitation SWI (ISWI) and other ATP-dependent chromatin-remodeling factors play key roles
in transcription and other processes by altering the structure and positioning of nucleosomes. …

Genetic variation modulating risk of sporadic Parkinson disease (PD) has been primarily
explored through genome-wide association studies (GWASs). However, like many other …

There is interest in discovering root traits associated with acclimation to nutrient stress.
Large root systems, such as in adult maize, have proven difficult to be phenotyped …

Examination of wild ancestors can identify which traits have been altered by selection as
possible targets for genetic improvement. We investigated the whole plant response to low …

Background There was ancient human selection on the wild progenitor of modern maize,
Balsas teosinte, for decreased shoot branching (tillering), in order to allow more nutrients to be …