More than 100 functionally distinct populations of lymphocytes can be identified in the
peripheral blood of humans; each of these cell types undoubtedly has a unique role in the …

Background. Recombinant DNA and modified vaccinia virus Ankara (rMVA) vaccines represent
a promising approach to an HIV/AIDS vaccine. This Phase 1 clinical trial compared the …

Establishing a CD8 + T cell–mediated immune correlate of protection in HIV disease is crucial
to the development of vaccines designed to generate cell-mediated immunity. Historically, …

Background In the RV144 trial, the estimated efficacy of a vaccine regimen against human
immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed a case–control analysis to …

Flow cytometric detection of antigen-specific CD8+ T cells has previously been limited to
MHC-class I tetramer staining or intracellular cytokine production, neither of which measure the …

Background. Clade B DNA and recombinant modified vaccinia Ankara (MVA) vaccines
producing virus-like particles displaying trimeric membrane-bound envelope glycoprotein (Env) …

Glutathione (GSH), a cysteine-containing tripeptide, is essential for the viability and function
of virtually all cells. In vitro studies showing that low GSH levels both promote HIV …

Background Efficacious vaccines are urgently needed to contain the ongoing coronavirus
disease 2019 (Covid-19) pandemic of infection with severe acute respiratory syndrome …

Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
raised concerns about resistance to neutralizing antibodies elicited by previous infection or …

The histories of monoclonal antibodies and the fluorescence activated cell sorter (FACS)
are as closely intertwined as their current uses in biology and medicine. Here, Leonore …