Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing
to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …
to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS …
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS …
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
Transactivating response region DNA binding protein (TDP-43) is the major protein
component of ubiquitinated inclusions found in amyotrophic lateral sclerosis (ALS) and …
component of ubiquitinated inclusions found in amyotrophic lateral sclerosis (ALS) and …
[PDF][PDF] Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins
Understanding how RNA binding proteins control the splicing code is fundamental to
human biology and disease. Here, we present a comprehensive study to elucidate how …
human biology and disease. Here, we present a comprehensive study to elucidate how …
[PDF][PDF] LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and
oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) …
oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) …
[HTML][HTML] Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS).
To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we …
To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we …
[PDF][PDF] SONAR discovers RNA-binding proteins from analysis of large-scale protein-protein interactomes
RNA metabolism is controlled by an expanding, yet incomplete, catalog of RNA-binding
proteins (RBPs), many of which lack characterized RNA binding domains. Approaches to …
proteins (RBPs), many of which lack characterized RNA binding domains. Approaches to …
[PDF][PDF] Protein-RNA networks regulated by normal and ALS-associated mutant HNRNPA2B1 in the nervous system
HnRNPA2B1 encodes an RNA binding protein associated with neurodegeneration.
However, its function in the nervous system is unclear. Transcriptome-wide crosslinking and …
However, its function in the nervous system is unclear. Transcriptome-wide crosslinking and …
[PDF][PDF] Resources for the comprehensive discovery of functional RNA elements
Transcriptome-wide maps of RNA binding protein (RBP)-RNA interactions by immunoprecipitation
(IP)-based methods such as RNA IP (RIP) and crosslinking and IP (CLIP) are key …
(IP)-based methods such as RNA IP (RIP) and crosslinking and IP (CLIP) are key …
Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl) imidazole at 2.0-Å resolution
…, PR Wilderman, L Sun, JY Yang, SC Huelga… - Molecular …, 2010 - ASPET
The structure of the K262R genetic variant of human cytochrome P450 2B6 in complex with
the inhibitor 4-(4-chlorophenyl)imidazole (4-CPI) has been determined using X-ray …
the inhibitor 4-(4-chlorophenyl)imidazole (4-CPI) has been determined using X-ray …