Immune history and influenza virus susceptibility

S Cobey, SE Hensley - Current opinion in virology, 2017 - Elsevier
… Author links open overlay panel Sarah Cobey 1 , Scott E Hensley 2 … Hensley, Ph.D. holds
an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome …

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

…, F Chen, SF Lacey, H Ramage, S Cherry, SE Hensley… - Science, 2020 - science.org
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

…, LA Vella, A Grifoni, D Weiskopf, A Sette, SE Hensley… - Science, 2021 - science.org
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease. However, …

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

…, MR Betts, ET Luning Prak, P Bates, SE Hensley… - Science …, 2021 - science.org
mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly limited …

[HTML][HTML] Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy

…, S Gouma, A Sette, P Bates, SE Hensley… - Nature medicine, 2021 - nature.com
… Vaccination in humans induces Ki67 + CD38 + CD4 and CD8 T cells approximately 1–2
weeks after Se immunization; this activated, proliferating subset contains antigen-specific T cells …

[PDF][PDF] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

…, JT Hamilton, MR Betts, P Bates, SE Hensley… - Immunity, 2021 - cell.com
SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific …

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

…, S Sahu, M Lifton, S Higgs, SE Hensley… - Nature, 2017 - nature.com
Zika virus (ZIKV) has recently emerged as a pandemic associated with severe neuropathology
in newborns and adults 1 . There are no ZIKV-specific treatments or preventatives. …

[HTML][HTML] CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer

…, RH Vonderheide, JD Wolchok, SE Hensley… - Nature medicine, 2021 - nature.com
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and
the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …

Comprehensive mapping of immune perturbations associated with severe COVID-19

…, EC Goodwin, EM Anderson, SE Hensley… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …

[PDF][PDF] Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

…, NJ Meyer, S Cherry, P Bates, DJ Rader, SE Hensley - Cell, 2021 - cell.com
… not associated with protection from SARS-CoV-2 infections It is unknown whether antibodies
elicited by prior hCoV infections protect against SARS-CoV-2 infections and/or prevent se