The role of cathepsin L in malignant transformation.
SE Kane, MM Gottesman - Seminars in cancer biology, 1990 - europepmc.org
Procathepsin L is the major excreted protein of malignantly transformed mouse fibroblasts
and it is one of the major acid cysteine proteases in mammalian cells. The broad general …
and it is one of the major acid cysteine proteases in mammalian cells. The broad general …
Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing
SE Kane, K Beemon - Molecular and cellular biology, 1985 - Am Soc Microbiol
… In a random sequence, PuGACU would occur once every 512 nt. In fact, in the entire PR-C …
Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 …
Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 …
CD30 Downregulation, MMAE Resistance, and MDR1 Upregulation Are All Associated with Resistance to Brentuximab Vedotin
…, X Liu, SH Thomas, SJ Forman, SE Kane - Molecular cancer …, 2015 - AACR
Brentuximab vedotin (BV) is an antibody–drug conjugate that specifically delivers the potent
cytotoxic drug monomethyl auristatin E (MMAE) to CD30-positive cells. BV is FDA approved …
cytotoxic drug monomethyl auristatin E (MMAE) to CD30-positive cells. BV is FDA approved …
The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells
D Sadava, E Whitlock, SE Kane - Biochemical and Biophysical Research …, 2007 - Elsevier
Epidemiological studies on humans and investigations in animal models suggest that
consumption of green tea has anti-cancer effects. Small-cell lung carcinoma (SCLC) has a poor …
consumption of green tea has anti-cancer effects. Small-cell lung carcinoma (SCLC) has a poor …
Transferrin overcomes drug resistance to artemisinin in human small-cell lung carcinoma cells
D Sadava, T Phillips, C Lin, SE Kane - Cancer letters, 2002 - Elsevier
Multiple drug resistance is a significant problem in small-cell lung cancer (SCLC). Artemisinin
(ART) is a natural product used to treat drug-resistant malaria. The drug is effective …
(ART) is a natural product used to treat drug-resistant malaria. The drug is effective …
Genetic basis of multidrug resistance of tumor cells
SE Kane, I Pastan, MM Gottesman - Journal of Bioenergetics and …, 1990 - Springer
Multidrug resistance in animal cells is defined as the simultaneous resistance to a variety of
compounds which appear to be structurally and mechanistically unrelated. One type of …
compounds which appear to be structurally and mechanistically unrelated. One type of …
Differential sensitivities of trastuzumab (Herceptin®)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor …
CT Chan, MZ Metz, SE Kane - Breast cancer research and treatment, 2005 - Springer
Her2 (erbB2/neu) is overexpressed in 25–30% of human breast cancers. Herceptin is a
recombinant humanized Her2 antibody used to treat breast cancer patients with Her2 …
recombinant humanized Her2 antibody used to treat breast cancer patients with Her2 …
[HTML][HTML] Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.
SJ Currier, SE Kane, MC Willingham… - Journal of Biological …, 1992 - Elsevier
The human MDR1 gene encodes the multidrug transporter (P-glycoprotein), a multidrug
efflux pump. The highly homologous MDR2 gene product does not appear to be a functional …
efflux pump. The highly homologous MDR2 gene product does not appear to be a functional …
Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells
D Sadava, DW Still, RR Mudry, SE Kane - Cancer Letters, 2009 - Elsevier
Multidrug resistance is a major problem in small-cell lung cancer (SCLC). Ganoderma
lucidum is a widely used herb is traditional Chinese medicine. We tested the effects of …
lucidum is a widely used herb is traditional Chinese medicine. We tested the effects of …
Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate
SF Eddy, SE Kane, GE Sonenshein - Cancer Research, 2007 - AACR
… The ratio of GFP-positive cells/total cells are presented as a mean ± SE normalized to empty
… SE normalized to empty vector untreated control cells (set to 1.0). Columns, mean; bars, SE. …
… SE normalized to empty vector untreated control cells (set to 1.0). Columns, mean; bars, SE. …