Loss of function of the gene SCN9A, encoding the voltage-gated sodium channel Na v 1.7,
causes a congenital inability to experience pain in humans. Here we show that Na v 1.7 is not …

The study of rare families with inherited pain insensitivity can identify new human-validated
analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for …

The voltage‐gated sodium channel Na V 1.7 plays a critical role in pain pathways. We
generated an epitope‐tagged Na V 1.7 mouse that showed normal pain behaviours to identify …

Background: Sensory neurons play an essential role in almost all pain conditions, and have
recently been classified into distinct subsets on the basis of their transcriptomes. Here we …

Chronic pain is a major global public health issue causing a severe impact on both the
quality of life for sufferers and the wider economy. Despite the significant clinical burden, little …

Several members of the ADAM (adisintegrin and metalloprotease) family of proteins have
been implicated in biological processes ranging from fertilization to myoblast fusion and neural …

Drive from peripheral neurons is essential in almost all pain states, but pharmacological
silencing of these neurons to effect analgesia has proved problematic. Reversible gene therapy …

Background: Somatosensation depends on primary sensory neurons of the trigeminal and
dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has …

The relationship between transcription and protein expression is complex. We identified
polysome-associated RNA transcripts in the somata and central terminals of mouse sensory …

Cancer pain is a growing problem, especially with the substantial increase in cancer survival.
Reports indicate that bone metastasis, whose primary symptom is bone pain, occurs in 65-…