This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis
complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo …

Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA
resistance (PZA-R) emerges in Mycobacterium tuberculosis strains with existing resistance to …

Here, we describe a clinical case of pyrazinamide-resistant (PZA-R) tuberculosis (TB) reported
as PZA-susceptible (PZA-S) by common molecular diagnostics. Phenotypic susceptibility …

… Another article by Susan Modlin, which discusses the author's personal experience with
a service dog training program, will be published in the January/February 2001 issue of …

Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other
antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The …

Whole-genome sequencing (WGS) is fundamental to Mycobacterium tuberculosis basic
research and many clinical applications. Coverage across Illumina-sequenced M. tuberculosis …

Background The genetic basis of virulence in Mycobacterium tuberculosis has been investigated
through genome comparisons of virulent (H37Rv) and attenuated (H37Ra) sister strains…

Accurate and timely functional genome annotation is essential for translating basic pathogen
research into clinically impactful advances. Here, through literature curation and structure-…

Point mutations in the rrs gene and the eis promoter are known to confer resistance to the
second-line injectable drugs (SLIDs) amikacin (AMK), capreomycin (CAP), and kanamycin (…

Lay theories or assumptions about nonhuman animal mentality undoubtedly influence
relations between people and companion animals. In two experiments respondents gave their …