A fundamental goal in biology is to understand the molecular basis of cell identity. Pluripotent
embryonic stem (ES) cell identity is governed by a set of transcription factors centred on …

Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog
expression. However, the mechanisms by which Nanog functions remain unclear, and in particular…

Most (epi)mutations in cancers are specific to particular tumours or occur at specific stages of
development, cell differentiation or tumorigenesis. Simple molecular mechanisms, such as …

Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered
on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have …

The generation of induced pluripotent stem (iPS) cells presents a challenge to normal
developmental processes. The low efficiency and heterogeneity of most methods have hindered …

The thymus is the central site of T-cell development and thus is of fundamental importance
to the immune system, but little information exists regarding molecular regulation of thymus …

Embryonic stem (ES) cell self‐renewal efficiency is determined by the Nanog protein level.
However, the protein partners of Nanog that function to direct self‐renewal are unclear. Here, …

The thymus is essential for a functional immune system, because the thymic stroma uniquely
supports T lymphocyte development. We have previously identified the epithelial progenitor …

Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …

To the Editor: The huge volume and complexity of data produced by high-throughput
sequencing make it difficult for researchers in many laboratories to fully harness the potential of …