Necroptosis and tumor progression
Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against
certain pathogen invasions. The deregulation of necroptosis is also a key factor of many …
certain pathogen invasions. The deregulation of necroptosis is also a key factor of many …
Switching on cilia: transcriptional networks regulating ciliogenesis
… For example, the yeasts S. cerevisiae and S. pombe both possess a single RFX factor but
no cilia. Conversely, there are multiple examples of Unikonta (eg Physarum polycephalum) …
no cilia. Conversely, there are multiple examples of Unikonta (eg Physarum polycephalum) …
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
… Surface biotinylation was performed according to the manufacturer’s instructions with
modifications using the Cell Surface Protein Isolation Kit (Pierce). Briefly, HT-29 cells (3×10 7 cells) …
modifications using the Cell Surface Protein Isolation Kit (Pierce). Briefly, HT-29 cells (3×10 7 cells) …
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
… ), which may limit its ability to activate the pathway(s) of ROS generation. More recently, RIP3
… for TNF-induced necrosis, but the downstream target(s) of these kinases are still unknown, …
… for TNF-induced necrosis, but the downstream target(s) of these kinases are still unknown, …
[HTML][HTML] TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death
Tumor necrosis factor (TNF) is an important cytokine in immunity and inflammation and
induces many cellular responses, including apoptosis and necrosis. TNF signaling enables the …
induces many cellular responses, including apoptosis and necrosis. TNF signaling enables the …
[HTML][HTML] Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation
The mechanism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely
unknown, although the mechanism of TNF-induced apoptosis has been studied extensively. In …
unknown, although the mechanism of TNF-induced apoptosis has been studied extensively. In …
[HTML][HTML] ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages
Y Zhang, S Choksi, K Chen, Y Pobezinskaya, I Linnoila… - Cell research, 2013 - nature.com
… had no effect on the production of IL-10 in M2 macrophages (Supplementary information,
Figure S4D), indicating that besides the ERK pathway, BHA affected additional pathway(s) that …
Figure S4D), indicating that besides the ERK pathway, BHA affected additional pathway(s) that …
MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation
MicroRNAs are key regulators of many biological processes, including cell differentiation.
Here we show that during human monocyte-macrophage differentiation, expression of the …
Here we show that during human monocyte-macrophage differentiation, expression of the …
[PDF][PDF] Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells
… To determine Prospero’s role in regulating these neuronal differentiation genes, we carried
out in situ hybridization on prospero mutant embryos. We find that Prospero is necessary for …
out in situ hybridization on prospero mutant embryos. We find that Prospero is necessary for …
Induction of autophagy is essential for monocyte-macrophage differentiation
…, MJ Morgan, K Chen, S Choksi… - Blood, The Journal of …, 2012 - ashpublications.org
Monocytes are programmed to undergo apoptosis in the absence of stimulation. Stimuli that
promote monocyte-macrophage differentiation not only cause cellular changes, but also …
promote monocyte-macrophage differentiation not only cause cellular changes, but also …