Reference population databases are an essential tool in variant and gene interpretation.
Their use guides the identification of pathogenic variants amidst the sea of benign variation …

Background: Most clinical overviews of acute bacterial meningitis have either focused on
children or all age groups combined, although the disease poses serious problems in the adult …

Despite advances in clinical genetic testing, including the introduction of exome sequencing
(ES), more than 50% of individuals with a suspected Mendelian condition lack a precise …

Current antimicrobial dosing regimens are designed to maintain active drug levels for most of
the dosing interval and are based on 40-y-old observations. With use of numerous multiple-…

… They were selected and developed by the author’s many years of experience in the aircraft
… In the author’s own design experience, a book such as this would have been extremely …

… We follow Lumpkin and Dess’s conceptualisation of EO based on five independent dimensions
which are distinct theoretical constructs that do not empirically need to covariate (Covin …

Objective: To study the correlation of antimicrobial consumption with the carriage rate of
penicillin resistant and multiresistant pneumococci in children. Design: Cross sectional and …

… The biomass reaction was used as an objective in the metabolic models, while the demand
of ribosomal 50 S subunit was used as the objective in the tr/tr models. In all cases, flux …

We provide a technique to efficiently produce high‐resolution three‐dimensional surface
motion maps by combining information about the motion of the Earth's surface from …

Objective: To estimate the frequency, duration, and clinical importance of postherpetic neuralgia
after a single episode of herpes zoster. Design: Prospective cohort study with long term …