Background There have been substantial improvements in the management of chronic
pancreatitis, leading to the publication of several national guidelines during recent years. In …

Hospitalized patients with acute medical conditions are at significant risk of venous
thromboembolism (VTE): approximately 10–30% of general medical patients may develop deep-vein …

Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

The original Lowry method of protein determination has been modified by the addition of
sodium dodecyl sulfate in the alkali reagent and an increase in the amount of copper tartrate …

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis 1 ,
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Mammalian genomes are organized into megabase-scale topologically associated
domains (TADs). We demonstrate that disruption of TADs can rewire long-range regulatory …

… The mobility in the saturation regime reaches 16.4 cm 2 V −1 s −1 on average, and the
maximum value is as high as 31.3 cm 2 V −1 s −1 . The on/off current ratio is 10 5 –10 7 , and the …

The functional complexity of the human transcriptome is not yet fully elucidated. We report a
high-throughput sequence of the human transcriptome from a human embryonic kidney and …

Background This phase 3 trial compared the efficacy and safety of rivaroxaban, an oral direct
inhibitor of factor Xa, with those of enoxaparin for extended thromboprophylaxis in patients …