… We find that repair is local, polarity sensitive, and prone to template switching, characteristics
that are consistent with gene conversion by synthesis-dependent strand annealing. Our …

… To our knowledge, less is known about demographic, socioeconomic, and psychiatric factors
which increase likelihood of marijuana use in older patients who use prescription opioids. …

CRISPR and associated Cas nucleases are genetic engineering tools revolutionizing
innovative approaches to cancer and inherited diseases. CRISPR-directed gene editing relies …

… Elucidation of mechanistic steps of DNA repair following a double-strand break is central
to our foundational understanding of the evolution of precise and imprecise genome …

… that SDSA is involved in HDR of DSBs generated by Cpf1-crRNA in plant cells when the
dsDNA is used as a DRT. Our observation that the left homologous arm alone is sufficient for …

… This is because worker bees and queens need to be maintained in colonies. Genetic …
Since our results suggest very high integration rates, it is possibly that larger inserts can …

… modified cells from the treated cell population is also technically challenging and time
consuming. The initial enrichment method is typically based on the selection of transfection-…

… qPCR was carried out as follows: 95C for 5 min, 40 cycles of (95C for 15 s and 60C for 30
s), followed by a melt curve stage: 95C for 15 s, 60C for 30 s and 95C for 15 s. The qPCR …

… ’s relevance in drug development and precision-medicine. With the aim to develop a tool to
better understand MRP1’s … Moreover, we tested if CF is an appropriate MRP1 substrate in an …