… ion cationic selectivity (P NA /P K > 20), a low urinary conductance (∼4–5 pS in the presence
of sodium), gating kinetics characterized by long closing and opening times (3–5 s) and, …

Checkpoint blockade mediates a proliferative response of tumor-infiltrating CD8 + T
lymphocytes (TILs). The origin of this response has remained elusive because chronic activation …

Introduction Breast cancer subtyping and prognosis have been studied extensively by gene
expression profiling, resulting in disparate signatures with little overlap in their constituent …

Chronic infections promote the terminal differentiation (or "exhaustion") of T cells and are
thought to preclude the formation of memory T cells. In contrast, we discovered a small …

… upregulated transcripts can be assigned to five groups of genes encoding: (1) heat shock
proteins, (2) cytochromes P450 (5 genes induced and 20 repressed), (3) glutathione S-…

Plant growth is strongly influenced by the presence of neighbors that compete for light
resources. In response to vegetational shading shade‐intolerant plants such as Arabidopsis …

Human mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via
unknown mechanisms. To define these pathways, we generated mice with a ventricular-…

… We report the draft sequence of the genome of the fire ant S. invicta, obtained by combined
Roche 454 and Illumina technologies for a sequencing cost of approximately $230,000. Our …

Sleep is regulated by a homeostatic process that determines its need and by a circadian
process that determines its timing. By using sleep deprivation and transcriptome profiling in …

… ’s serum. (C) Merged hypocretin-serum staining showing that the vast majority of
hypocretin-positive neurons are costained by the patient’s … (H) Immunoreactivity with the same …