Transcription factors are key cellular components that control gene expression: their activities
determine how cells function and respond to the environment. Currently, there is great …

… Finally, evaluating the correlation between each gene’s expression level in bulk-level
control data, if it exists, and the gene’s average expression across single cells can provide …

… tend to have clearer transcriptional signatures of G1/S versus G2/M stages, whereas fast-…
of the cell cycle in each cell by comparing expression levels of G1/S versus G2/M genes 35 . …

This study describes comprehensive polling of transcription start and termination sites and
analysis of previously unidentified full-length complementary DNAs derived from the mouse …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

… In our view, the antibodies used passed both the manufacturer’s validation and our internal
validation. Proper ISH cell targeting using IF for ACE2 confirmed expected localization to …

10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …