Platinum nanoparticles: a promising material for future cancer therapy?

…, Y Furusawa, C Le Sech, S Lacombe - …, 2010 - iopscience.iop.org
Recently, the use of gold nanoparticles as potential tumor selective radiosensitizers has been
proposed as a breakthrough in radiotherapy. Experiments in living cells and in vivo have …

AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

…, E Porcel, S Lacombe… - The British journal of …, 2019 - birpublications.org
AGuIX ® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium
chelates. This nanoparticle has been recently accepted in clinical trials in association with …

Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

…, Z Kuncic, S Kunjachan, S Lacombe… - Physics in Medicine …, 2020 - iopscience.iop.org
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of
radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z= 22, to Bismuth, …

[HTML][HTML] RAC1 inhibition targets amyloid precursor protein processing by γ-secretase and decreases Aβ production in vitro and in vivo

…, T Taverne, E Beausoleil, S Lacombe… - Journal of Biological …, 2005 - ASBMB
β-Amyloid peptides (Aβ) that form the senile plaques of Alzheimer disease consist mainly of
40- and 42-amino acid (Aβ 40 and Aβ 42) peptides generated from the cleavage of the …

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

…, F Denat, C Louis, E Porcel, S Lacombe… - The British journal of …, 2014 - birpublications.org
A new efficient type of gadolinium-based theranostic agent (AGuIX®) has recently been
developed for MRI-guided radiotherapy (RT). These new particles consist of a polysiloxane …

[HTML][HTML] Nanoparticle radio-enhancement: principles, progress and application to cancer treatment

Z Kuncic, S Lacombe - Physics in Medicine & Biology, 2018 - iopscience.iop.org
Enhancement of radiation effects by high-atomic number nanoparticles (NPs) has been
increasingly studied for its potential to improve radiotherapeutic efficacy. The underlying …

Gadolinium-based nanoparticles to improve the hadrontherapy performances

…, Y Furusawa, C Le Sech, S Li, S Lacombe - … , Biology and Medicine, 2014 - Elsevier
Nanomedicine is proposed as a novel strategy to improve the performance of radiotherapy.
High-Z nanoparticles are known to enhance the effects of ionizing radiation. Recently, …

[HTML][HTML] Particle therapy and nanomedicine: state of art and research perspectives

S Lacombe, E Porcel, E Scifoni - Cancer nanotechnology, 2017 - Springer
Cancer radiation therapy with charged particle beams, called particle therapy, is a new
therapeutic treatment presenting major advantages when compared to conventional radiotherapy…

[HTML][HTML] Cell localisation of gadolinium-based nanoparticles and related radiosensitising efficacy in glioblastoma cells

…, M Réfrégiers, O Tillement, F Lux, S Lacombe - Cancer …, 2014 - Springer
Recently, the addition of nanoparticles (NPs) has been proposed as a new strategy to
enhance the effect of radiotherapy particularly in the treatment of aggressive tumors such as …

[HTML][HTML] Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells

L Štefančíková, S Lacombe, D Salado, E Porcel… - Journal of …, 2016 - Springer
Background Tumor targeting of radiotherapy represents a great challenge. The addition of
multimodal nanoparticles, such as 3 nm gadolinium-based nanoparticles (GdBNs), has been …