The population history of Aboriginal Australians remains largely uncharacterized. Here we
generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama–Nyungan …

We investigate the effect of spatial range expansions on the evolution of fitness when beneficial
and deleterious mutations cosegregate. We perform individual‐based simulations of 1 D …

The Out-of-Africa (OOA) dispersal ∼50,000 y ago is characterized by a series of founder
events as modern humans expanded into multiple continents. Population genetics theory …

Expanding populations incur a mutation burden – the so‐called expansion load. Previous
studies of expansion load have focused on codominant mutations. An important consequence …

Expanding populations incur a mutation burden, the so-called expansion load. Using a
mixture of individual-based simulations and analytical modeling, we study the expansion load …

Recent theoretical work suggested that deleterious mutations could accumulate during the
range expansion of a species, negatively affecting its fitness. Recent theory predicts that the …

Linked selection is a major driver of genetic diversity. Selection against deleterious mutations
removes linked neutral diversity (background selection [BGS]) [1], creating a positive …

A factor that may limit the ability of many populations to adapt to changing conditions is the
rate at which beneficial mutations can become established. We study the probability that …

Peischl et al. explore the way evolutionary forces shape genetic variability in expanding human
populations. Over a few generations of separate evolution... Humans have colonized the …

Increased human activities caused the isolation of populations in many species—often
associated with genetic depletion and negative fitness effects. The effects of isolation are …