Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50…

In chronic viral infections, CD8 + T cells become functionally deficient and display multiple
molecular alterations. In contrast, only little is known of self- and tumor-specific CD8 + T cells …

DNA sequence variation has been associated with quantitative changes in molecular
phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. …

Chromatin state variation at gene regulatory elements is abundant across individuals, yet we
understand little about the genetic basis of this variability. Here, we profiled several histone …

Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2
cells is important for understanding the pathogenesis of immune-mediated diseases, such …

Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) experiments are
widely used to determine, within entire genomes, the occupancy sites of any protein of interest…

Background Chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-seq)
is increasingly being applied to study transcriptional regulation on a genome-wide …

The molecular role of corepressors is poorly understood. Here, we studied the transcriptional
function of the corepressor SMRT during terminal adipogenesis. Genome-wide DNA-…

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation
prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying molecular …

10.7554/eLife.03346.001 Adipose tissue is a key determinant of whole body metabolism
and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is …