Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung
volume and is used to diagnose and monitor lung diseases. We performed genome-wide …

Obsessive–compulsive disorder (OCD) affects 1–2% of the population, and, as with other
complex neuropsychiatric disorders, it is thought that rare variation contributes to its genetic risk…

Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host
Genetics Initiative genome-wide association study used common variants to identify multiple …

Background Cardiovascular health (CVH) has been defined by the American Heart Association
(AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is …

Background Treatment and preventative advances for chronic obstructive pulmonary disease
(COPD) have been slow due, in part, to limited subphenotypes. We tested if unsupervised …

Background Genome sequencing coupled with electronic heath record data can uncover
medically important genetic variation. Interpretation of rare genetic variation and its role in …

Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease;
however, there are few studies on the associations of cardiovascular genes with COPD. We …

Background: function to date, many of which have also been implicated in chronic obstructive
pulmonary disease. We carried out meta-analyses of exome array data and three lung …

Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD);
whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of …

Background Inherited cardiomyopathies display variable penetrance and expression, and a
component of phenotypic variation is genetically determined. To evaluate the genetic …