Robustness is the invariance of phenotypes in the face of perturbation. The robustness of
phenotypes appears at various levels of biological organization, including gene expression, …

Genetic architecture, the structure of the mapping from genotype to phenotype, determines
the variational properties of the phenotype and is instrumental in understanding its …

Background. Adjuvant chemotherapy is established routine therapy for colon cancer (CC)
patients with radically resected stage III and ‘high-risk’ stage II disease. The decision on …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

This article considers the statistical issues relevant to the comparative method in evolutionary
biology. A generalized linear model (GLM) is presented for the analysis of comparative …

… This assumption is also shared with a large class of comparative methods based on
reconstruction of character states on the phylogeny (Martins and Hansen 1996a). The selective re…

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

The Lande equation forms the basis for our understanding of the short‐term evolution of
quantitative traits in a multivariate context. It predicts the response to selection as the product of …