User profiles for T. G. Clark

Taane G. Clark

Professor of Genomics & Global Health, London School of Hygiene and Tropical Medicine
Verified email at lshtm.ac.uk
Cited by 40520

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

…, ET Dermitzakis, L Armengol, CP Bird, TG Clark… - nature, 2007 - nature.com
We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

[HTML][HTML] Survival analysis part I: basic concepts and first analyses

TG Clark, MJ Bradburn, SB Love, DG Altman - British journal of cancer, 2003 - nature.com
In many cancer studies, the main outcome under assessment is the time to an event of
interest. The generic name for the time is survival time, although it may be applied to the time ‘…

[HTML][HTML] Survival analysis part II: multivariate data analysis–an introduction to concepts and methods

MJ Bradburn, TG Clark, SB Love, DG Altman - British journal of cancer, 2003 - nature.com
Survival analysis involves the consideration of the time between a fixed starting point (eg
diagnosis of cancer) and a terminating event (eg death). The key feature that distinguishes …

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

…, JG Pasipanodya, C Rodrigues, TG Clark… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis
remains out of control in several parts of the world including Africa and Asia. Although …

[HTML][HTML] Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice

…, DJ Pickard, SH Duncan, HJ Flint, TG Clark… - PLoS …, 2012 - journals.plos.org
Relapsing C. difficile disease in humans is linked to a pathological imbalance within the
intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that mice …

[HTML][HTML] A robust SNP barcode for typing Mycobacterium tuberculosis complex strains

…, I Portugal, A Pain, N Martin, TG Clark - Nature …, 2014 - nature.com
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an
important factor in pathogenesis that may affect virulence, transmissibility, host response and …

A transcriptional switch underlies commitment to sexual development in malaria parasites

BFC Kafsack, N Rovira-Graells, TG Clark, C Bancells… - Nature, 2014 - nature.com
The life cycles of many parasites involve transitions between disparate host species, requiring
these parasites to go through multiple developmental stages adapted to each of these …

[HTML][HTML] Survival analysis part III: multivariate data analysis–choosing a model and assessing its adequacy and fit

MJ Bradburn, TG Clark, SB Love, DG Altman - British journal of cancer, 2003 - nature.com
In this series of papers, we have described a selection of statistical methods used for the
initial analysis of survival time data (Clark et al, 2003), and introduced a selection of more …

[HTML][HTML] Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

…, CV Plowe, JC Rayner, KA Rockett, TG Clark… - Nature, 2012 - nature.com
Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis

MR Munafo, TG Clark, LR Moore, E Payne… - Molecular …, 2003 - nature.com
A meta-analysis was conducted on studies reporting data on associations between
candidate genes and human personality. Studies reporting data for psychiatric populations (…