The HIV-1 envelope protein gp120 induces apoptosis in hippocampal neurons. Because
chemokine receptors act as cellular receptors for HIV-1, we examined rat hippocampal neurons …

Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological
profile. Whereas the molecular basis for their anesthetic actions remains unclear, they …

To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to
generate mice lacking this metabotropic receptor subtype (mGluR7 −/− ). After the serendipitous …

The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult
human central nervous system (CNS). Tau splicing is developmentally regulated and …

Primary neuronal cultures are an invaluable in vitro tool for examining the fundamental
physiological changes that occur in diseases of the central nervous system. In this work, we have …

Aims Growing evidence suggests an association between the use of sedative‐hypnotic
medications and risk of dementia. The aim of this study is to examine this association using a …

Eight subtypes of metabotropic glutamate (mGlu) receptors have been identified of which
two, mGlu5 and mGlu7, are highly expressed at synapses made between CA3 and CA1 …

Simple Summary Interleukin-16 is a protein involved in the migration of some immune cells
and plays an important role in the development of multiple sclerosis, an inflammatory …

1 An understanding of the physiological and pathological roles of metabotropic glutamate
receptors (mGluRs) is currently hampered by the lack of selective antagonists. Standard …

Proteinase-activated receptors (PARs1–4) have recently been identified as the molecular
entity underlying the cellular effects of serine proteinases. In the present study we have …