With the emergence of multiply resistant Staphylococcus aureus, there is an urgent need to
better understand the molecular determinants of S. aureus pathogenesis. A model of …

A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus
aureus in a zebrafish model - Prajsnar - 2012 - Cellular Microbiology - Wiley Online …

Autophagy, a catabolic pathway of lysosomal degradation, acts not only as an efficient recycle
and survival mechanism during cellular stress, but also as an anti-infective machinery. …

All bacterial infections occur within a polymicrobial environment, from which a pathogen
population emerges to establish disease within a host. Emphasis has been placed on …

To slow the inexorable rise of antibiotic resistance we must understand how drugs impact on
pathogenesis and influence the selection of resistant clones. Staphylococcus aureus is an …

Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on
the autophagy machinery of the host. This response is studied intensively in epithelial cells, …

S. aureus is a highly successful pathogen that is speculated to be the most common cause
of human disease. The progression of disease in S. aureus is subject to multi-factorial …

Lysozyme is a key component of the innate immune response in humans that provides a first
line of defense against microbes. The bactericidal effect of lysozyme relies both on the cell …

Mononuclear phagocytes such as monocytes, tissue-specific macrophages, and dendritic
cells are primary actors in both innate and adaptive immunity. These professional phagocytes …

Staphylococcus aureus is a major human pathogen causing multiple pathologies, from
cutaneous lesions to life-threatening sepsis. Although neutrophils contribute to immunity against …