Transposable elements (TEs) were first discovered more than 50 years ago, but were totally
ignored for a long time. Over the last few decades they have gradually attracted increasing …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Circulating proteins are vital in human health and disease and are frequently used as
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we …

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health.
To date, most genetic studies of glycemic traits have focused on individuals of European …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood
pressure to identify genes, tissues, phenomes and medication contexts of blood pressure …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly
understood mechanisms. We performed a trans-ancestry genome-wide association study …

Transposable elements are often considered parasitic DNA sequences, able to invade the
genome of their host thanks to their self-replicating ability. This colonization process has been …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we …

Background The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based
population cohort with DNA, biological samples, socio-demographic, psychological …