Cyclic peptides are among the most diverse architectures for current drug discovery efforts.
Their size, stability, and ease of synthesis provide attractive scaffolds to engage and …

We use computational design coupled with experimental characterization to systematically
investigate the design principles for macrocycle membrane permeability and oral …

Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent
therapeutics identified to date, but there is currently no way to systematically search the structural …

A major role for the intracellular post-translational modification O-GlcNAc appears to be the
inhibition of protein aggregation. Most of the previous studies in this area focused on O-…

Despite recent success in computational design of structured cyclic peptides, de novo design
of cyclic peptides that bind to any protein functional site remains difficult. To address this …

The rise of antibiotic resistance calls for new therapeutics targeting resistance factors such
as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial enzyme that degrades β-lactam …

New chemical inhibitors of protein–protein interactions are needed to propel advances in
molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to inhibit …

Despite the increasing number of GPCR structures and recent advances in peptide design,
the development of efficient technologies allowing rational design of high-affinity peptide …

Synthetic proteins bearing site-specific posttranslational modifications have revolutionized
our understanding of their biological functions in vitro and in vivo. One such modification, O-…

Peptidomimetics are classes of molecules that mimic structural and functional attributes of
polypeptides. Peptidomimetic oligomers can frequently be synthesized using efficient solid …